Article
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.
The Journal of cell biology - 31 Dec 2007
Howell Gareth R, Libby Richard T, Jakobs Tatjana C, Smith Richard S, Phalan F Campbell, Barter Joseph W, Barbay Jessica M, Marchant Jeffrey K, Mahesh Nagaraju, Porciatti Vittorio, Whitmore Alan V, Masland Richard H, John Simon W M
Abstract excerpt
Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using BAX-deficient DBA/2J mice, which retain all of their RGCs,...
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