Article

Individual-Specific Gaussian Graphical Models for Heterogeneous Populations with Application to Epigenetic Gene Regulation in Lung Adenocarcinoma

2026-05-28

Abstract excerpt

Inter-patient molecular heterogeneity is a fundamental challenge in precision oncology: population-level multi-omics networks reveal average biology aggregated across the population but obscure individual variations that drive differential clinical outcomes. We introduce SIREN (Sample-specific Inference via Regularized Empirical-Bayes Networks), a method that estimates one partial correlation network per sample ac...

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Literature Corpus work: 0cfab8b4-657d-53db-b6ce-c0d62eb9de17
DOI: 10.64898/2026.05.25.727641

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