Article

The central role of cancer driver genes in pathway networks according to persistence homology

2023-11-09

Abstract excerpt

<title>Abstract</title> <p>Cancer is a complex disease caused by mutations accumulated over a lifetime. Albeit cancer cells harbor many mutations, only a small fraction, called driver mutations, are responsible for the emergence and maintenance of the disease. Pathway networks are subsets from the whole cell interactome and represent meaningful biological functions. In this study, we explore the topological compl...

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Literature Corpus work: 0cf0ecdc-2935-5d2b-883c-7bb42b585299
DOI: 10.21203/rs.3.rs-3088203/v2

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