Cancer relevance of human genes

Abstract excerpt

<h4>Background</h4> It is unclear how many of genes contribute to the biology of cancer. We hypothesize that genes that interact with core cancer gene (CCG) in a protein-protein interaction network (PPI) may have functional importance. <h4>Methods</h4> We categorized genes into 1- (n=6791), 2- (n=7724), 3- (n=1587), and >3-steps (n=362) removed from the nearest CCG in the STRING PPI and demonstrate that the canc...

Topics

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• Databases, Genetic
• Gene Regulatory Networks
• Genes, Neoplasm
• Genomics
• Germ-Line Mutation
• Mutation
• Mutation Rate
• Neoplasms

Identifiers and source

Literature Corpus work

b7acb007-2a76-5761-9be5-e715f54b4fd5

DOI

10.1101/2021.02.04.429823