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Article

Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights.

Endocrinology - 1 Oct 2017

Groeneweg Stefan, Lima de Souza Elaine C, Meima Marcel E, Peeters Robin P, Visser W Edward, Visser Theo J

Abstract excerpt

Monocarboxylate transporter 8 (MCT8) facilitates cellular uptake and efflux of thyroid hormone (TH). Mutations in MCT8 result in severe intellectual and motor disability known as the Allan-Herndon-Dudley syndrome (AHDS). Previous studies have provided valuable insights into the putative mechanism of substrate binding in the inward-open conformation, required for TH efflux. The current study aims to delineate the...

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Identifiers

PMID: 28977587
DOI: 10.1210/en.2017-00082

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