Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants.

Frontiers in cellular and infection microbiology - 1 Jan 2018

Viljoen Albertus, Gutiérrez Ana Victoria, Dupont Christian, Ghigo Eric, Kremer Laurent

Abstract excerpt

Little is known about the disease-causing genetic determinants that are used by Mycobacterium abscessus, increasingly acknowledged as an important emerging pathogen, notably in cystic fibrosis. The presence or absence of surface exposed glycopeptidolipids (GPL) conditions the smooth (S) or rough (R) M. abscessus subsp. abscessus (M. abscessus) variants, respectively, which are characterized by distinct infective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Bacterial
Share to Glycolipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycopeptides

Share to Homologous Recombination

Share to Hydrophobic and Hydrophilic Interactions

Share to Mycobacterium Infections, Nontuberculous

Share to Nervous System

Share to Transformation, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 29594066
DOI: 10.3389/fcimb.2018.00069
PMCID: PMC5861769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants.PMID 29594066Read ↗

Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune responseSemantic proximity Read ↗

GplR1, an unusual TetR-like transcription factor in Mycobacterium abscessus, controls the production of cell wall glycopeptidolipids, colony morphology, and virulenceSemantic proximity Read ↗

Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus ComplexSemantic proximity Read ↗

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.Semantic proximity Read ↗

GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus</i> , controls the production of cell wall glycopeptidolipids, colony morphology, and virulenceSemantic proximity Read ↗

Silencing essential gene expression in Mycobacterium abscessus during infectionSemantic proximity Read ↗

Smooth-to-rough morphotype switching, a mechanism of phage resistance in Mycobacterium abscessus.Semantic proximity Read ↗

Lipid metabolic pathways determine phage infectivity in <i>Mycobacterium abscessus</i>Semantic proximity Read ↗

Construction of <i>Mycobacterium abscessus</i> Defined Glycopeptidolipid Mutants: Comparison of Genetic ToolsSemantic proximity Read ↗

Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesisSemantic proximity Read ↗

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

A highly conserved two-gene operon is crucial for lipoarabinomannan localization, pathogenesis, and cell envelope function in <i>Mycobacterium abscessus</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.