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Astro-Versus Microglia-Enriched Transcriptomes from Aged <em>Atxn2</em>-CAG100-knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies

2026-03-03

Abstract excerpt

Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis type 13 (ALS13) are triggered by polyglutamine expansion in Ataxin-2 (ATXN2). To understand these neurodegenerative disorders at the molecular level, the brains of 10-month-old Atxn2-CAG100-knockin mice were analyzed as microglial, astroglial and neuronal fractions via global RNA sequencing. Data were validated by comparison with spinal cord ol...

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Literature Corpus work
0cdc24f7-f6a6-5949-b40c-8d6a45e533ec
DOI
10.20944/preprints202603.0256.v1
Open publication

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Astro-Versus Microglia-Enriched Transcriptomes from Aged <em>Atxn2</em>-CAG100-knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-BodiesDOI 10.20944/preprints202603.0256.v1
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