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Article

Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.

PLoS genetics - 1 Apr 2015

Dansithong Warunee, Paul Sharan, Figueroa Karla P, Rinehart Marc D, Wiest Shaina, Pflieger Lance T, Scoles Daniel R, Pulst Stefan M

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells (PCs) and other neurons caused by expansion of a glutamine (Q) tract in the ATXN2 protein. We generated BAC transgenic lines in which the full-length human ATXN2 gene was transcribed using its endogenous regulatory machinery. Mice with the ATXN2 BAC transgene with an expanded CAG...

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Source

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Identifiers

PMID: 25902068
DOI: 10.1371/journal.pgen.1005182
PMCID: PMC4406435

Genes

ATXN2
RGS8
ITPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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