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Article

Genotype frequencies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemotherapy.

Basic & clinical pharmacology & toxicology - 1 Jul 2010

Afsar Nasir Ali, Haenisch Sierk, Mateen Ahmed, Usman Ahmed, Ufer Mike, Ahmed Khwaja Zafar, Ahmad Hakimuddin Razi, Cascorbi Ingolf

Abstract excerpt

Polymorphic genes of drug metabolizing enzymes and transporters may influence drug response. With some exemptions, single nucleotide polymorphisms in such genes, however, are not known to be susceptibility factors for breast cancer. This study explored genotype profiles for the breast cancer patients on fluorouracil, doxorubicin and cyclophosphamide (FAC) in a Pakistani set of population and their comparison with...

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Share to Aldehyde Dehydrogenase
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophosphamide

Share to Cytochrome P-450 CYP2C9

Share to Doxorubicin

Share to Fluorouracil

Share to Inactivation, Metabolic

Share to Multidrug Resistance-Associated Protein 2

Source

Identifiers

PMID: 20102361
DOI: 10.1111/j.1742-7843.2009.00531.x

Genes

ABCB1
ABCC2
GSTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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