Article
Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array.
European journal of clinical pharmacology - 1 Oct 2018
Kalra Sourav, Kaur Raman Preet, Ludhiadch Abhilash, Shafi Gowhar, Vashista Rajesh, Kumar Raj, Munshi Anjana
Abstract excerpt
PURPOSE: Cyclophosphamide and doxorubicin (adjuvant chemotherapy) are commonly used to treat breast cancer patients. Variation in the genes involved in pharmacodynamics and pharmacokinetics of these drugs plays an important role in prediction of drug response and survival. The present study was carried out with an aim to evaluate the variation in all the genes involved in pharmacokinetic and pharmacodynamics...
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