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Article

Pharmacogenetics of Chemotherapy Efficacy in Breast Cancer

1 Apr 2012

Abstract excerpt

Large differences are observed in chemotherapy response between breast cancer patients, with a substantial part of this variability being explained by genetic factors. Polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters and drug targets influence the pharmacokinetics and pharmacodynamics of these anticancer drugs, leading to differences in therapeutic efficacy. Pharmacogenetic...

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PMID: 22515610
DOI: 10.2217/pgs.12.44

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