LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2

Abstract excerpt

<title>Abstract</title><p>Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are deregulated in hepatocellular carcinoma (HCC) and play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the current understanding of the role of lncRNAs in NAFLD-associated HCC is limited. In this study, transcriptomic profiling analysis of three paired human liver samples from patients...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Lipids, and Metabolism
• Cancer-related molecular mechanisms research
• Endoplasmic Reticulum Stress and Disease
• Lipid metabolism and disorders
• Liver Disease Diagnosis and Treatment
• MicroRNA in disease regulation
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

952ff908-7f3b-5f9f-9fb4-8ed58c179a0f

DOI

10.21203/rs.3.rs-2051343/v1