Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis.

doi:10.1007/s00125-023-05925-4

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Article

Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis.

Diabetologia - 1 Aug 2023

Yarmolinsky James, Bouras Emmanouil, Constantinescu Andrei, Burrows Kimberley, Bull Caroline J, Vincent Emma E, Martin Richard M, Dimopoulou Olympia, Lewis Sarah J, Moreno Victor, Vujkovic Marijana, Chang Kyong-Mi, Voight Benjamin F, Tsao Philip S, Gunter Marc J, Hampe Jochen, Pellatt Andrew J, Pharoah Paul D P, Schoen Robert E, Gallinger Steven, Jenkins Mark A, Pai Rish K, Gill Dipender, Tsilidis Kostas K

Abstract excerpt

AIMS/HYPOTHESIS: Epidemiological studies have generated conflicting findings on the relationship between glucose-lowering medication use and cancer risk. Naturally occurring variation in genes encoding glucose-lowering drug targets can be used to investigate the effect of their pharmacological perturbation on cancer risk. METHODS: We developed genetic instruments for three glucose-lowering drug targets...

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PMID: 37171501
DOI: 10.1007/s00125-023-05925-4
PMCID: PMC10317892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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