Article

Subcellular transcriptome sequencing with single cell APEX-seq identifies regulators of cell-cell interactions

2026-03-18

Abstract excerpt

Single-cell RNA sequencing has transformed our understanding of tissue complexity and heterogeneous cell states, yet provides little information about the subcellular organization of transcriptomes - despite the central role of RNA localization in splicing, translation, and function. Here we introduce single-cell APEX-seq (scAPEX-seq), a proximity labeling-based method for mapping subcellular transcriptomes at sin...

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Literature Corpus work: 597d9e3e-c254-553f-8b73-d8d8dea7e533
DOI: 10.64898/2026.03.17.712496

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