Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics

Abstract excerpt

Subcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation. However, methods for high-throughput mapping of mRNA localization within intact tissue sections remain limited. Here, we apply high-resolution spatial transcriptomics (VisiumHD) to systematically resolve intracellular mRNA localization acros...

Topics

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• Barrier Structure and Function Studies
• Gene Expression Profiling
• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology
• Phenotype
• Single-cell and spatial transcriptomics
• Technology
• Transcriptome

Identifiers and source

Literature Corpus work

95a9b3c3-092c-5f40-ac5c-4e889e049971

DOI

10.1101/2025.09.07.674688