Article

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

2022-11-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background：</bold>The third most often diagnosed disease globally and the second most prevalent cause of cancer-related death is colorectal cancer (CRC). Numerous human malignancies have been identified to overexpress ADORA2A. However, it is still ambiguous about its function in CRC. <bold>Methods: </bold>RNA-seq with stable transfected SETDB1 knockdown cells was used to identify...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7af3bced-4e00-5719-a49e-e6f7d70980c9
DOI: 10.21203/rs.3.rs-2224036/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinomaDOI 10.21203/rs.3.rs-2224036/v1Read

ASXL2 promotes colorectal cancer tumorigenesis by inducing cell proliferationSemantic proximity Read

SH2D2A as a VEGF pathway-related oncogene driving colorectal cancer through mTOR activationSemantic proximity Read

Navigating the interplay between BCL-2 family proteins, apoptosis, and autophagy in colorectal cancerSemantic proximity Read

Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathwaySemantic proximity Read

Comprehensive clinical analysis of AKR1 expression profiles in the diagnosis of human colorectal cancerSemantic proximity Read

Evaluation of lncRNA FOXD2-AS1 expression as a diagnostic biomarker in CRCSemantic proximity Read

SPOCD1 accelerates colorectal cancer by increasing the expression of YAPSemantic proximity Read

Colorectal cancer on a dish: exploring the 3D-sphere culture of primary colorectal cancer cells from an Indonesian perspectiveSemantic proximity Read

Aurka orchestrates colorectal cancer progression through dual regulation of tumor proliferation and immune microenvironmentSemantic proximity Read

UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancerSemantic proximity Read

Cell division cycle associated 5 promotes colorectal cancer progression by activating the ERK signaling pathwaySemantic proximity Read

SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expressionSemantic proximity Read