Article

MyoRep: a novel reporter system to detect early muscle atrophy <i>in vitro</i> and <i>in vivo</i>

2025-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Muscle atrophy occurs during physiological (i.e., fasting, aging) and pathological (i.e., amyotrophic lateral sclerosis, cancer) conditions and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early. We have studied the promoters/enhancers of a subset of atrophy-related genes or atrogenes upregulated in muscles of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c7ad755-3f91-571a-ba94-c964cfa63921
DOI: 10.1101/2025.02.27.640021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MyoRep: a novel reporter system to detect early muscle atrophy <i>in vitro</i> and <i>in vivo</i>DOI 10.1101/2025.02.27.640021Read

Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolismSemantic proximity Read

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseasesSemantic proximity Read

Identification of ubiquitin ligases required for skeletal muscle atrophy.Semantic proximity Read

Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis.Semantic proximity Read

UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from AtrophySemantic proximity Read

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 <i>Drosophila</i> modelSemantic proximity Read

The beneficial effect of chronic muscular exercise on muscle fragility is increased by <i>Prox1</i> gene transfer in dystrophic <i>mdx</i> muscleSemantic proximity Read

DNA repair byproduct 8-oxoguanine base promotes myogenic differentiation via OGG1-mediated activation of RAS-MEK-MyoD signaling pathwaySemantic proximity Read

A Muscle Hybrid Promoter as a Novel Tool for Gene TherapySemantic proximity Read

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophySemantic proximity Read

MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiationSemantic proximity Read

IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.Semantic proximity Read