Article

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Skeletal muscle regeneration in chronic muscle diseases such as Duchenne Muscular Dystrophy (DMD) has remained clinically unsurmountable. Estrogen-related receptor alpha (ERRα) plays a critical role in adult skeletal muscle metabolism and exercise fitness. Whether ERRα activation can drive muscle regeneration and mitigation of dystrophy in DMD is not known. We have investigated ERRα signaling in...

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Literature Corpus work: 9c150355-b3d7-5321-ba81-87378becded6
DOI: 10.1101/2025.05.15.654390

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