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Article

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 <i>Drosophila</i> model

18 Jun 2015

Abstract excerpt

Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat...

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PMID: 26092529
DOI: 10.1242/dmm.018127

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