Article

Developmental control of DNA damage responses in α- and β-cells shapes the selective beta-cell susceptibility in diabetes

2025-11-12

Abstract excerpt

Accumulation of DNA damage drives β-cell dysfunction, senescence, and death in Type 1 and Type 2 diabetes. While α-cell dysfunction also contributes to disease pathology, they remain remarkably resistant to senescence and cell-death. The mechanisms underlying these differential responses to diabetogenic stress, particularly differences in their DNA damage vulnerability, remain unclear. We demonstrate that replicat...

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Literature Corpus work: 0c7a90e1-3212-5c72-805b-1b75c591f388
DOI: 10.1101/2025.11.10.687707

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