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Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

27 Oct 2010

Abstract excerpt

β-Cell regeneration declines with aging, but the molecular mechanisms controlling β-cell replication in humans are not well understood. We compared the expression of selected cell cycle proteins in prenatal and adult tissue and examined the association of these proteins with β-cell replication. Pancreatic tissue from a total of 20 human fetuses and adults was stained for Ki67, cyclin D3, p16 and p27, and insulin....

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PMID: 20978233
DOI: 10.1152/ajpendo.00496.2010

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