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Article

Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension.

Vascular pharmacology - 1 Aug 2016

Happé C M, Szulcek R, Voelkel N F, Bogaard H J

Abstract excerpt

In pulmonary arterial hypertension (PAH) structural and functional abnormalities of the small lung vessels interact and lead to a progressive increase in pulmonary vascular resistance and right heart failure. A current pathobiological concept characterizes PAH as a 'quasi-malignant' disease focusing on cancer-like alterations in endothelial cells (EC) and the importance of their acquired apoptosis-resistant,...

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Share to Angiogenic Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Mechanotransduction, Cellular

Share to Neovascularization, Pathologic

Share to Pulmonary Artery

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Source

Identifiers

PMID: 26804008
DOI: 10.1016/j.vph.2016.01.004

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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