Article

Deamidation at N53 Causes SOD1 Structural Instability and Excess Zn Incorporation

2025-10-01

Abstract excerpt

<h4>Background: </h4> /Objectives: Approximately 20% of familial ALS (fALS) cases are linked to mutations to Cu/Zn superoxide dismutase (SOD1). Through a gain function, SOD1 misfolding exerts a toxic effect on motor neurons, leading to their degradation and ALS symptomology in both fALS cases and sporadic ALS (sALS) cases with no known genetic cause. To further our understanding of SOD1-ALS etiology, identifying m...

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Literature Corpus work: 7ed9e941-be69-5513-92ca-467a3a429a34
DOI: 10.20944/preprints202510.0093.v1

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