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Article

Metal distribution in Cu/Zn-superoxide dismutase revealed by native mass spectrometry.

Free radical biology & medicine - 1 Apr 2022

Tajiri Michiko, Aoki Hiroto, Shintani Atsuko, Sue Kaori, Akashi Satoko, Furukawa Yoshiaki

Abstract excerpt

Cu/Zn-superoxide dismutase (SOD1) is a homodimer with two identical subunits, each of which binds a copper and zinc ion in the native state. In contrast to such a text book case, SOD1 proteins purified in vitro or even in vivo have been often reported to bind a non-stoichiometric amount of the metal ions. Nonetheless, it is difficult to probe how those metal ions are distributed in the two identical subunits. By...

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PMID: 35314356
DOI: 10.1016/j.freeradbiomed.2022.03.014

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