Article

EOLA1, a novel mitochondria-localized protein critical for heart functions via regulating mitochondrial translation

2026-01-12

Abstract excerpt

Mitochondria possess their own mRNA translation system, mediated by specialized mitoribosomes. Dysregulation of mitochondrial translation disrupts metabolic homeostasis and is linked to various pathologies, including metabolic syndromes, neurological disorders, and cardiac diseases. Using CRISPR/Cas9 screening, we identified EOLA1 (endothelial-overexpressed lipopolysaccharide-associated factor 1) as a novel mitoch...

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Literature Corpus work: 0c5c279c-d7fe-581a-859e-0a9c64244a83
DOI: 10.64898/2026.01.12.699056

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