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Article

Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease.

Bioscience trends - 15 May 2023

Liu Yuzhao, Zhao Xiangli, Jian Jinlong, Hasan Sadaf, Liu Chuanju

Abstract excerpt

Gaucher disease (GD), one of the most common lysosomal storage diseases, is caused by GBA1 mutations resulting in defective glucocerebrosidase (GCase) and consequent accumulation of its substrates β-glucosylceramide (β-GlcCer). We reported progranulin (PGRN), a secretary growth factor-like molecule and an intracellular lysosomal protein was a crucial co-factor of GCase. PGRN binds to GCase and recruits Heat Shock...

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Topics

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Share to Gaucher Disease
Share to GBA1 gene
Share to Glucosylceramidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomes

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Share to Protein Disulfide-Isomerases

Source

Open in PubMed Open full text

Identifiers

PMID: 36889696
DOI: 10.5582/bst.2023.01022
PMCID: PMC10514708

Genes

GBA1
PDIA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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