Article
Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.
Hippocampus - 1 Jun 2011
Nogami Tatsuya, Beppu Hideyuki, Tokoro Takashi, Moriguchi Shigeki, Shioda Norifumi, Fukunaga Kohji, Ohtsuka Toshihisa, Ishii Yoko, Sasahara Masakiyo, Shimada Yutaka, Nishijo Hisao, Li En, Kitajima Isao
Abstract excerpt
Mutations of the ATRX gene, which encodes an ATP-dependent chromatin-remodeling factor, were identified in patients with α-thalassemia X-linked mental retardation (ATR-X) syndrome. There is a milder variant of ATR-X syndrome caused by mutations in the Exon 2 of the gene. To examine the impact of the Exon 2 mutation on neuronal development, we generated ATRX mutant (ATRX(ΔE2)) mice. Truncated ATRX protein was...
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