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Article

Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.

Disease models & mechanisms - 1 Feb 2017

Tamming Renee J, Siu Jennifer R, Jiang Yan, Prado Marco A M, Beier Frank, Bérubé Nathalie G

Abstract excerpt

The rapid modulation of chromatin organization is thought to play a crucial role in cognitive processes such as memory consolidation. This is supported in part by the dysregulation of many chromatin-remodelling proteins in neurodevelopmental and psychiatric disorders. A key example is ATRX, an X-linked gene commonly mutated in individuals with syndromic and nonsyndromic intellectual disability. The consequences...

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Identifiers

PMID: 28093507
DOI: 10.1242/dmm.027482
PMCID: PMC5312007

Genes

ATRX

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