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Article

The challenge of intratumour heterogeneity in precision medicine

25 Mar 2014

Abstract excerpt

Cells within tumours have diverse genomes and epigenomes and interact differentially with their surrounding microenvironment generating intratumour heterogeneity, which has critical implications for treating cancer patients. Understanding the cellular and microenvironment composition and characteristics in individual tumours is critical to stratify the patient population that is likely to benefit from specific...

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PMID: 24661605
DOI: 10.1111/joim.12240

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