Article

Astrocytic MAOB-GABA axis as a molecular brake on repair following spinal cord injury

2025-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Neuroregeneration and remyelination rarely occur in the adult mammalian brain and spinal cord following central nervous system (CNS) injury. The glial scar has been proposed as a major contributor to this failure in the regenerative process. However, its underlying molecular and cellular mechanisms remain unclear. Here, we report that monoamine oxidase B (MAOB)-dependent excessive GABA release f...

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Literature Corpus work: 0bca59d2-66d3-58e1-be11-5be7fcfbb8e3
DOI: 10.1101/2025.02.25.637603

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