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Attenuation of Reactive Astrogliosis Accompanies Neurological Recovery Induced by Novel Poly-Target 2,3-Benzodiazepines After Experimental Traumatic Brain Injury

2026-07-01

Abstract excerpt

<title>Abstract</title> <p>Introduction. Traumatic brain injury (TBI) generates multifactorial secondary pathophysiology, which monotherapies have consistently failed to address. We evaluated MPTD-01 and BS34-20, novel 2,3-benzodiazepine derivatives with a computationally predicted multi-target profile, in a moderate TBI rat model. Methods. Male Wistar rats (n = 120) were allocated to five groups: Intact (n = 5...

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Literature Corpus work: 79d7aa85-ae41-504a-864b-79204d52f27a
DOI: 10.21203/rs.3.rs-10044242/v1

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