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Article

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

Nature - 28 Sept 2017

Kim Sangdoo, Kim Hyunju, Yim Yeong Shin, Ha Soyoung, Atarashi Koji, Tan Tze Guan, Longman Randy S, Honda Kenya, Littman Dan R, Choi Gloria B, Huh Jun R

Abstract excerpt

Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In pregnant mice, interleukin-17a (IL-17a) produced by T helper 17 (TH17) cells (CD4+ T helper...

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Identifiers

PMID: 28902840
DOI: 10.1038/nature23910
PMCID: PMC5870873

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MIA

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