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Article

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.

Science (New York, N.Y.) - 26 Feb 2016

Choi Gloria B, Yim Yeong S, Wong Helen, Kim Sangdoo, Kim Hyunju, Kim Sangwon V, Hoeffer Charles A, Littman Dan R, Huh Jun R

Abstract excerpt

Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled in rodents subjected to maternal immune activation (MIA). The immune cell populations critical in the MIA model have not been identified. Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor-related orphan nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Receptor Subfamily 1, Group F, Member 3

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Source

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Identifiers

PMID: 26822608
DOI: 10.1126/science.aad0314
PMCID: PMC4782964

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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