Article

Deletion of the gene for the African swine fever virus BCL-2 family member A179L increases virus uptake and apoptosis, but decreases virus spread in macrophages and reduces virulence in pigs

2023-04-28

Abstract excerpt

<h4>ABSTRACT</h4> African swine fever virus encodes proteins that inhibit apoptosis including one member of the BCL-2 family, A179L. Deletion of the A179L gene from the virulent genotype I isolate Benin 97/1 compared to Benin 97/1 expressing A179L or mock-infected macrophages, resulted in increased Caspase 3 and 7 activity, annexin V binding to surface phosphatidyl serine and DNA fragmentation, measured by termin...

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Literature Corpus work: 0ba87d98-8f00-5566-ae05-c1890727326e
DOI: 10.1101/2023.04.27.538639

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