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African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis

8 Nov 2021

Abstract excerpt

African swine fever (ASF) is a severe hemorrhagic disease in swine characterized by massive lymphocyte depletion and cell death, with apoptosis and necrosis in infected lymphoid tissues. However, the molecular mechanism regarding ASFV-induced cell death remains largely unknown. In this study, 94 ASFV-encoded proteins were screened to determine the viral proteins involved in cell death in vitro, and pE199L showed...

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PMID: 34835046
DOI: 10.3390/v13112240

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