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Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis

5 Jan 2017

Abstract excerpt

ABSTRACT Programmed cell death is a tightly controlled process critical for the removal of damaged or infected cells. Pro- and antiapoptotic proteins of the Bcl-2 family are pivotal mediators of this process. African swine fever virus (ASFV) is a large DNA virus, the only member of the Asfarviridae family, and harbors A179L, a putative Bcl-2 like protein. A179L has been shown to bind to several proapoptotic Bcl-2...

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PMID: 28053104
DOI: 10.1128/jvi.02228-16

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