Article
Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation.
Scientific reports - 8 Dec 2015
Chang Pengxiang, Kuchipudi Suresh V, Mellits Kenneth H, Sebastian Sujith, James Joe, Liu Jinhua, Shelton Holly, Chang Kin-Chow
Abstract excerpt
Pigs are evidently more resistant to avian than swine influenza A viruses, mediated in part through frontline epithelial cells and alveolar macrophages (AM). Although porcine AM (PAM) are crucial in influenza virus control, their mode of control is unclear. To gain insight into the possible role of PAM in the mediation of avian influenza virus resistance, we compared the host effects and replication of two avian...
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