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Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution

4 May 2022

Abstract excerpt

African swine fever virus (ASFV) is the causative agent of African swine fever, a highly contagious and usually fatal disease in pigs. The pathogenesis of ASFV infection has not been clearly elucidated. Here, we used single-cell RNA-sequencing technology to survey the transcriptomic landscape of ASFV-infected primary porcine alveolar macrophages. The temporal dynamic analysis of viral genes revealed increased...

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PMID: 35507870
DOI: 10.1073/pnas.2201288119

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