Article

SERCA activity is reduced in <i>DJ-1</i> mutant flies and human cells due to oxidative modification

2020-11-19

Abstract excerpt

<h4>ABSTRACT</h4> DJ-1 is a causative gene for familial Parkinson’s disease (PD) with different functions, standing out its role against oxidative stress (OS). Accordingly, PD model flies harboring a mutation in the DJ-1β gene (the Drosophila ortholog of human DJ-1 ) show high levels of OS markers like protein carbonylation, a common post-translational modification that may alter protein function. To increase...

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Literature Corpus work: 0b8f4469-173b-551b-8a2b-f2003639c2ad
DOI: 10.1101/2020.11.19.389841

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