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Article

Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson's disease.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jul 2021

Solana-Manrique Cristina, Muñoz-Soriano Verónica, Sanz Francisco José, Paricio Nuria

Abstract excerpt

DJ-1 is a causative gene for familial Parkinson's disease (PD) with different functions, standing out its role against oxidative stress (OS). Accordingly, PD model flies harboring a mutation in the DJ-1β gene (the Drosophila ortholog of human DJ-1) show high levels of OS markers like protein carbonylation, a common post-translational modification that may alter protein function. To increase our understanding of...

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Identifiers

PMID: 33892078
DOI: 10.1016/j.bbadis.2021.166152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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