Article

Analysis of Regions of Homozygosity: Revisited Through New Bioinformatic Approaches

2024-10-14

Abstract excerpt

Runs of homozygosity (ROH) are contiguous homozygous segments occurring throughout the genome. ROH's number and size heavily depend upon shared parental ancestry, particularly relevant in the context of parental consanguinity. Homozygosity mapping, a valuable technique for the identification of genes associated with human genetic diseases, is based on the presence of ROH. Next-generation sequencing (NGS) impr...

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Literature Corpus work: 0b41e9b6-147f-5b7c-9c58-9beea8d356da
DOI: 10.20944/preprints202410.0870.v1

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