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LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling

2020-04-15

Abstract excerpt

Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that is either associated with the clonal integration of the Merkel cell polyomavirus or with chronic sun exposure 1,2 . Immunotherapy is initially effective in many patients with metastatic MCC, but the response is rarely durable 3,4 . MCC lacks actionable mutations that could be utilized for targeted therapies, but epigenetic regula...

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Literature Corpus work
0b2f6748-eec3-5674-84dc-d7bbe3915d62
DOI
10.1101/2020.04.14.041657
Open publication

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LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signalingDOI 10.1101/2020.04.14.041657
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