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Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

30 Jun 2022

Abstract excerpt

Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I-low, neuroendocrine carcinoma of the skin often caused by the Merkel cell polyomavirus (MCPyV). Through the characterization of 11 newly generated MCC patient-derived cell lines, we identified transcriptional suppression of several class...

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PMID: 35775490
DOI: 10.1172/jci151666

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