Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Pathogenesis of Merkel Cell Carcinoma.

Annual review of pathology - 24 Jan 2021

DeCaprio James A

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with two distinct etiologies. Clonal integration of Merkel cell polyomavirus DNA into the tumor genome with persistent expression of viral T antigens causes at least 60% of all MCC. UV damage leading to highly mutated genomes causes a nonviral form of MCC. Despite these distinct etiologies, both forms of MCC are similar in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Carcinoma, Merkel Cell
Share to Full-Duplex Wireless Communications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polyomavirus and related diseases

Share to Polyomavirus Infections

Share to Skin Neoplasms

Share to Tumor Virus Infections

Source

Identifiers

PMID: 33228463
DOI: 10.1146/annurev-pathmechdis-012419-032817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Pathogenesis of Merkel Cell Carcinoma.PMID 33228463Read ↗

Update on Merkel Cell Carcinoma.Semantic proximity Read ↗

Merkel cell carcinoma: an updated overview of clinico-pathological aspects, molecular genetics and therapy.Semantic proximity Read ↗

Merkel Cell Carcinoma from Molecular Pathology to Novel TherapiesSemantic proximity Read ↗

Mutational Analysis of Merkel Cell CarcinomaSemantic proximity Read ↗

Mutational Landscape of Virus- and UV-Associated Merkel Cell Carcinoma Cell Lines Is Comparable to Tumor TissueSemantic proximity Read ↗

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas.Semantic proximity Read ↗

Merkel cell carcinoma.Semantic proximity Read ↗

Danger is only skin deep: aggressive epidermal carcinomas. An overview of the diagnosis, demographics, molecular-genetics, staging, prognostic biomarkers, and therapeutic advances in Merkel cell carcinoma.Semantic proximity Read ↗

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.Semantic proximity Read ↗

Merkel Cell Polyomavirus‒Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine DifferentiationSemantic proximity Read ↗

The complex conundrum of Merkel cell carcinoma cellular ancestrySemantic proximity Read ↗

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.