Article

Contribution of the neuron-specific ATP1A3 to embryonic spinal circuit emergence

2024-06-11

Abstract excerpt

The early neurodevelopmental contributions of ion pumps remain poorly characterized. Combining analysis of public human embryo single-cell transcriptomic datasets and an embryonic chicken model, we found a conserved differentiation sequence whereby spinal cord neurons switch on neuron-specific alpha3 subunit (ATP1A3) of Na + /K + ATPases. In the chicken model, ATP1A3 is distributed along axons and growth cones....

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Literature Corpus work: 0a974b1c-8df3-5341-af2b-f071471bb790
DOI: 10.1101/2024.06.11.598491

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