Article

A Decision-Aid Model for Predicting Triple-Negative Breast Cancer ICI Response Based on Tumor Mutation Burden

2025-02-10

Abstract excerpt

Background: Tumor mutation burden (TMB), a genomic biomarker, has proven to be a strong predictor of immunotherapy response but is not widely adopted. This study investigates the association between TMB and immune checkpoint inhibitors (ICIs) response in TNBC patients. Methods: From the TCGA database, patients were stratified into two levels based on TMB and validated using survival analysis. Then, four machine le...

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Literature Corpus work: 0a8492e8-e21f-5df8-acc5-a8918ae045c6
DOI: 10.3390/biomedinformatics5010009

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