Article

Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer

1999-01-06

Abstract excerpt

Inducible Ca 2+ -independent nitric oxide synthase (NOS), also referred to as NOS2, which is expressed in a variety of human cancers ( 1 - 4 ), can generate mutagenic concentrations of nitric oxide (NO) in mice ( 5 ). NOS2 is the most active isoform among the three known nitric oxide synthases ( 6 ), which also include the neuronal (NOS1) and endothelial (NOS3) isoforms. Only NOS2 is capable of producing sustained...

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Literature Corpus work: 0a6fac36-6f06-5ef0-869c-078e1ff8de30
DOI: 10.1093/jnci/91.1.86

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