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RESPONSE: Re: Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer

1 Sept 1999

Abstract excerpt

Cellular expression of inducible nitric oxide synthase, also called NOS2, has recently been shown in various types of human cancer ( 1 - 4 ). NOS2 was mainly found in tumor-infiltrating monocytes and endothelial cells of breast, gastric, and colon tumors ( 1 , 2 ) but was most commonly detected in the epithelium of esophageal ( 3 ) and head and neck ( 4 ) carcinomas. Thus, tumor-associated nitric oxide production...

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PMID: 10469758
DOI: 10.1093/jnci/91.17.1510

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