Article
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Ambs S, Ogunfusika M O, Merriam W G, Bennett W P, Billiar T R, Harris C C
Abstract excerpt
High concentrations of nitric oxide (NO) cause DNA damage and apoptosis in many cell types. Thus, regulation of NO synthase (NOS) activity is essential for minimizing effects of cytotoxic and genotoxic nitrogen oxide species. We have shown previously that NO-induced p53 protein accumulation down-...
Topics
- Animals
- Feedback
- Gene Expression Regulation, Enzymologic
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neoplasms, Experimental
- Nitric Oxide
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Promoter Regions, Genetic
- Up-Regulation