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Article

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998

Ambs S, Ogunfusika M O, Merriam W G, Bennett W P, Billiar T R, Harris C C

Abstract excerpt

High concentrations of nitric oxide (NO) cause DNA damage and apoptosis in many cell types. Thus, regulation of NO synthase (NOS) activity is essential for minimizing effects of cytotoxic and genotoxic nitrogen oxide species. We have shown previously that NO-induced p53 protein accumulation down-regulates basal and cytokine-modulated inducible NOS (NOS2) expression in human cells in vitro. To further characterize...

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Share to Promoter Regions, Genetic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 9671763
DOI: 10.1073/pnas.95.15.8823
PMCID: PMC21161

Genes

NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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