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Humanized rabbit entry receptor complex supports HIV-1 entry into rabbit cells

2025-10-30

Abstract excerpt

<title>Abstract</title> <p> Rabbits show promise as a model species for HIV-1, but exhibit a major block to infection at the level of viral entry. Here, minimally modified rabbit CD4 and CCR5 were sufficient to overcome this barrier and allowed efficient HIV-1 entry into rabbit cells.Based on <italic>in silico</italic> comparative structural modeling and sequence analysis, we generated several human-rabbit CD4...

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Literature Corpus work
0a6542b4-1a09-5ed2-8e1e-1ff16dd0f21f
DOI
10.21203/rs.3.rs-7973543/v1
Open publication

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Humanized rabbit entry receptor complex supports HIV-1 entry into rabbit cellsDOI 10.21203/rs.3.rs-7973543/v1
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